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2001 1
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2009 5
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Page 1
TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma.
Grewal R, Choung HYG, Roberts LL, Beane T, Chen L, Gilroy DX, Rappold PM, Le TH. Grewal R, et al. Acta Oncol. 2022 Dec;61(12):1507-1511. doi: 10.1080/0284186X.2022.2143279. Epub 2022 Nov 11. Acta Oncol. 2022. PMID: 36369873
We report our findings of TMEM27 expression in ccRCC and clinical outcomes in an independent third cohort. ...TMEM27 may be a useful biomarker to assess cancer prognosis. Further studies are needed to better assess if TMEM27 is protective in RCC, and its pote …
We report our findings of TMEM27 expression in ccRCC and clinical outcomes in an independent third cohort. ...TMEM27 may be a …
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort.
Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Wang YT, Chen L, Wassertheil-Smoller S, Cai J, Isakson BE, Franceschini N, Le TH. Chu PL, et al. Am J Physiol Renal Physiol. 2023 Jan 1;324(1):F30-F42. doi: 10.1152/ajprenal.00176.2022. Epub 2022 Oct 20. Am J Physiol Renal Physiol. 2023. PMID: 36264884 Free PMC article.
Collectrin (Tmem27), an angiotensin-converting enzyme 2 homologue, is a chaperone of amino acid transporters in the kidney and endothelium. ...In the present study, we generated PT-specific collectrin KO (PT KO) mice to determine the precise contribution of PT colle …
Collectrin (Tmem27), an angiotensin-converting enzyme 2 homologue, is a chaperone of amino acid transporters in the kidney and …
Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury.
Pajenda S, Wagner L, Gerges D, Herkner H, Tevdoradze T, Mechtler K, Schmidt A, Winnicki W. Pajenda S, et al. Life (Basel). 2022 Sep 6;12(9):1391. doi: 10.3390/life12091391. Life (Basel). 2022. PMID: 36143426 Free PMC article.
Acute kidney injury (AKI) is a leading complication in hospitalized patients of different disciplines due to various aetiologies and is associated with the risk of chronic kidney disease, the need for dialysis and death. Since nephrons are not supplied with pain sig …
Acute kidney injury (AKI) is a leading complication in hospitalized patients of different disciplines due to various aetiologies and …
Kidney amino acid transport.
Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM. Verrey F, et al. Pflugers Arch. 2009 May;458(1):53-60. doi: 10.1007/s00424-009-0638-2. Epub 2009 Jan 28. Pflugers Arch. 2009. PMID: 19184091 Review.
Near complete reabsorption of filtered amino acids is a main specialized transport function of the kidney proximal tubule. This evolutionary conserved task is carried out by a subset of luminal and basolateral transporters that together form the transcellular amino acid tr …
Near complete reabsorption of filtered amino acids is a main specialized transport function of the kidney proximal tubule. This evolu …
Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.
Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH. Chu PL, et al. J Am Soc Nephrol. 2017 Jun;28(6):1826-1837. doi: 10.1681/ASN.2016060675. Epub 2017 Jan 6. J Am Soc Nephrol. 2017. PMID: 28062568 Free PMC article.
We previously reported that global deletion of collectrin leads to endothelial dysfunction, augmented salt sensitivity, and hypertension. Here, we performed kidney crosstransplants between wild-type (WT) and collectrin knockout (Tmem27(Y/-) ) mice to delineate the s …
We previously reported that global deletion of collectrin leads to endothelial dysfunction, augmented salt sensitivity, and hypertension. He …
Collectrin and ACE2 in renal and intestinal amino acid transport.
Singer D, Camargo SM. Singer D, et al. Channels (Austin). 2011 Sep-Oct;5(5):410-23. doi: 10.4161/chan.5.5.16470. Epub 2011 Sep 1. Channels (Austin). 2011. PMID: 21814048 Free article. Review.
Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. ...We will in particular focus on the situation of B0AT1 and B0AT3, that associate with members of th …
Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they …
Locus heterogeneity of Dent's disease: OCRL1 and TMEM27 genes in patients with no CLCN5 mutations.
Tosetto E, Addis M, Caridi G, Meloni C, Emma F, Vergine G, Stringini G, Papalia T, Barbano G, Ghiggeri GM, Ruggeri L, Miglietti N, D Angelo A, Melis MA, Anglani F. Tosetto E, et al. Pediatr Nephrol. 2009 Oct;24(10):1967-73. doi: 10.1007/s00467-009-1228-4. Epub 2009 Jul 7. Pediatr Nephrol. 2009. PMID: 19582483
The recent discovery of a novel mediator of renal amino acid transport, collectrin (the TMEM27 gene), may provide new insight on the pathogenesis of Dent's disease. ...No TMEM27 gene mutations were discovered among 26 patients, 20 of whom had an incomplete Dent's di …
The recent discovery of a novel mediator of renal amino acid transport, collectrin (the TMEM27 gene), may provide new insight on the …
Role of collectrin, an ACE2 homologue, in blood pressure homeostasis.
Chu PL, Le TH. Chu PL, et al. Curr Hypertens Rep. 2014 Nov;16(11):490. doi: 10.1007/s11906-014-0490-4. Curr Hypertens Rep. 2014. PMID: 25182162 Free PMC article. Review.
Collectrin (Tmem27) is a transmembrane glycoprotein that is highly expressed in the kidney and vascular endothelium. It is a homologue of the angiotensin-converting enzyme 2 (ACE2) but harbors no catalytic domain. In the extravascular tissues of the kidney, c …
Collectrin (Tmem27) is a transmembrane glycoprotein that is highly expressed in the kidney and vascular endothelium. It is a h …
Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.
Javorhazy A, Farkas N, Beothe T, Pusztai C, Szanto A, Kovacs G. Javorhazy A, et al. J Cancer Res Clin Oncol. 2016 Sep;142(9):1947-53. doi: 10.1007/s00432-016-2207-3. Epub 2016 Jul 14. J Cancer Res Clin Oncol. 2016. PMID: 27417314

In multivariate analysis, only T stadium and TMEM27 staining showed a significant association with postoperative cancer-specific death (p < 0.001). CONCLUSIONS: Lack of expression of the TMEM27 in conventional RCC defines a group of patients at high risk for canc

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In multivariate analysis, only T stadium and TMEM27 staining showed a significant association with postoperative cancer-specific deat …
Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.
Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F. Camargo SM, et al. Gastroenterology. 2009 Mar;136(3):872-82. doi: 10.1053/j.gastro.2008.10.055. Epub 2008 Oct 29. Gastroenterology. 2009. PMID: 19185582 Free PMC article.
BACKGROUND & AIMS: Hartnup amino acid transporter B(0)AT1 (SLC6A19) is the major luminal sodium-dependent neutral amino acid transporter of small intestine and kidney proximal tubule. The expression of B(0)AT1 in kidney was recently shown to depend on its associ …
BACKGROUND & AIMS: Hartnup amino acid transporter B(0)AT1 (SLC6A19) is the major luminal sodium-dependent neutral amino acid transporter …
23 results